Search results for "Probability of success"
showing 8 items of 8 documents
ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability.
2020
In silico prediction of human oral bioavailability is a relevant tool for the selection of potential drug candidates and for the rejection of those molecules with less probability of success during the early stages of drug discovery and development. However, the high variability and complexity of oral bioavailability and the limited experimental data in the public domain have mainly restricted the development of reliable in silico models to predict this property from the chemical structure. In this study we present a KNIME automated workflow to predict human oral bioavailability of new drug and drug-like molecules based on five machine learning approaches combined into an ensemble model. Th…
Probabilistic and team PFIN-type learning: General properties
2008
We consider the probability hierarchy for Popperian FINite learning and study the general properties of this hierarchy. We prove that the probability hierarchy is decidable, i.e. there exists an algorithm that receives p_1 and p_2 and answers whether PFIN-type learning with the probability of success p_1 is equivalent to PFIN-type learning with the probability of success p_2. To prove our result, we analyze the topological structure of the probability hierarchy. We prove that it is well-ordered in descending ordering and order-equivalent to ordinal epsilon_0. This shows that the structure of the hierarchy is very complicated. Using similar methods, we also prove that, for PFIN-type learning…
Pure donation or hybrid donation crowdfunding
2019
PurposeDespite the growing research exploring the possibility and feasibility of financing socially oriented projects through crowdfunding, relatively little research examines which crowdfunding model is better to serve such purpose. The purpose of this paper is to offer novel insights to mitigate this research gap.Design/methodology/approachA unique data set collected from the largest Chinese crowdfunding platform is used to test the hypotheses. To solve the perceived self-selection problem, the propensity score matching method is adopted in this paper. Based on this approach, the results of similar prosocial campaigns in two different models (pure donation and hybrid donation) are compare…
Traditional endodontic surgery versus modern technique: a 5-year controlled clinical trial.
2014
In this study, we compared outcomes of traditional apicoectomy versus modern apicoectomy, by means of a controlled clinical trial with a 5-year follow-up. The study investigated 938 teeth in 843 patients. On the basis of the procedure performed, the teeth were grouped in 3 groups. Differences between the groups were the method of osteotomy (type of instruments used), type of preparation of retrograde cavity (different apicoectomy angles and instruments used for root-end preparation), and root-end filling material used (gray mineral trioxide aggregate or silver amalgam). Outcome (tooth healing) was estimated after 1 and 5 years, postoperatively. Clinical success rates after 1 year were 67% (…
Conditional generation of non-classical states in a nondegenerate two-photon micromaser: single-mode Fock states preparation. II
1997
Abstract A conditional generation of single-mode Fock states in the framework of a non-degenerate two-photon micromaser theory is reported. The exact expression for the probability of success of the experiment is obtained. We show that it is possible to conjugate experimentally interesting values of this probability, with the generation of number states having a controllable high intensity. This objective is reached by constructing analytically detailed rules about the cavity state at t = 0 as well as the atom–field interaction times as functions of the available operating conditions. These rules play a central role in our Fock-state-building process, leading to an essential countering of t…
The role of linkages in firm performance: evidence from southern Italy
2000
Abstract This paper estimates the probability of success of post-entry performance of new firms, using survey data from a group of southern-Italian small firms. Several factors involving inter-firm linkages contribute to success, especially production for order and subcontracting. The empirical investigation supports Hirschman’s idea on the industrialization process and positive assessments of the downsizing phenomenon in Italy.
Bayesian Design of “Successful” Replications
2002
Replication of experiments is commonin applied research. However, systematic studies of the goals and motivations of a “replication” are rare. As a consequence, there does not seem to be a precise notion of what a “success” when replicating means. This article discusses some of the possible goals for replication; this leads to different (but precise) notions of “success” when replicating. Bayesian hierarchical models allow for a flexible and explicit incorporation of the assumed relationship among the experiments. Bayesian predictive distributions are a natural tool to compute the probability of the replication being successful, and hence to design the replication so that the probability of…
More is not always better—non-linear effects in crowdfunding
2019
Abstract This research focuses on crowdfunding project features and its relation with the success of this project. The main purpose is to improve probability of success of crowdfunding projects. One can argue that “more is always better” resulting in attempts of daily updates. Contrarily, backers may be weary of numerous updates to work through, indicating a possible wear-out effect, implying the existence of an optimal level of updates. Our preliminary results show that previous research, built upon linear modeling, widely ignores important aspects of the relationship between key variables. We therefore picked six key variables that were previously marked as success drivers in crowdfunding…